MOLECULAR PATHOGENESIS OF EBV SUSCEPTIBILITY IN XLP AS REVEALED BY ANALYSIS OF FEMALE CARRIERS WITH HETEROZYGOUS EXPRESSION OF SAP.

Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP.

X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D1A which encodes SAP.SAP functions in signalling pathways elicited by the SLAM family of leukocyte receptors.A defining feature of XLP is exquisite sensitivity to infection with EBV, a B-lymphotropic virus, but not other viruses.Although previous stu

read more


Targeted and Untargeted Metabolomics Profiling of Wheat Reveals Amino Acids Increase Resistance to Fusarium Head Blight

Fusarium head blight (FHB), a notorious plant disease caused by Fusarium graminearum (F.graminearum), is severely harmful to wheat production, resulting in a decline in grain quality and yield.In order to develop novel control strategies, metabolomics has been increasingly used to characterize more comprehensive profiles of the mechanisms of underl

read more